Publications

2022


Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression. Comba, A., Faisal, S.M., Dunn, P.J. Argento AE, Hollon TC et al. Nature Communications 13, 3606 (2022).


Rapid Automated Analysis of Skull Base Tumor Specimens Using Intraoperative Optical Imaging and Artificial Intelligence Jiang, Cheng MS*; Bhattacharya, Abhishek BS‡, et al.. Neurosurgery: March 30, 2022 - Volume - Issue - 10.1227



2021


Denoising stimulated Raman histology using weak supervision to improve label-free optical microscopy of human brain tumors. Esteban Urias (University of Michigan); Christopher Freudiger (Invenio Imaging Inc.); Daniel Orringer (New York University); Honglak Lee (University of Michigan); Todd Hollon (University of Michigan). Machine Learning for Healthcare Conference Proceedings 2020.



Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications. Comba A, Faisal SM, Varela ML, Hollon T, Al-Holou WN, Umemura Y, Nunez FJ, Motsch S, Castro MG, Lowenstein PR.

Front Oncol. 2021 Aug 5


Lateral Suboccipital Craniotomy With C1-C2 Hemilaminectomies and C1-C3 Fusion for the Treatment of a C1-C2 Synovial Cyst Causing Spinal Cord Compression: 2-Dimensional Operative Video.

Croci DM, Fredrickson VL, Hollon TC, Dailey AT, Couldwell WT.

Oper Neurosurg (Hagerstown). 2021 Jun 23


Idiopathic chronic temporal lobe herniation with associated epilepsy.Gamblin A, Fredrickson VL, Hollon TC, Salzman KL, Couldwell WT.

Acta Neurochir (Wien). 2021 Jul 22.


Abstract PR005: The dynamic tumor microenvironment: Oncostreams are self-organizing structures that modulate glioma progression and treatment

A Comba, S Motsch, P Dunn, T Hollon, D Zamler, A Argento, A Kahana, ...

Cancer Research 81 (5 Supplement), PR005-PR005. 2021


SYSTEMS AND METHODS FOR ANALYSIS AND REMOTE INTERPRETATION OF OPTICAL HISTOLOGIC IMAGES

D Orringer, B Pandian, C Freudiger, T Hollon

US Patent App. 16/967,052.2021



Label-free brain tumor imaging using Raman-based methods

T Hollon, DA Orringer

Journal of neuro-oncology 151 (3), 393-402. 2021



Rapid, label-free detection of diffuse glioma recurrence using intraoperative stimulated Raman histology and deep neural networks

TC Hollon, B Pandian, E Urias, AV Save, AR Adapa, S Srinivasan, ...

Neuro-oncology 23 (1), 144-155. 2021



Normal cerebral ventricular volume growth in childhood

NS Cutler, S Srinivasan, BL Aaron, SK Anand, MS Kang, DB Altshuler, ...

Journal of Neurosurgery: Pediatrics 26 (5), 517-524. 2021



Volumetric quantification of aneurysmal subarachnoid hemorrhage independently predicts hydrocephalus and seizures.

Daou BJ, Khalsa SSS, Anand SK, Williamson CA, Cutler NS, Aaron BL, Srinivasan S, Rajajee V, Sheehan K, Pandey AS.J Neurosurg. 2021 Feb 5:1-9.



2020


An automated tissue-to-diagnosis pipeline using intraoperative stimulated Raman histology and deep learning

TC Hollon, DA Orringer

Molecular & cellular oncology 7 (3), 1736742.2020



Automated histologic diagnosis of CNS tumors with machine learning

SSS Khalsa, TC Hollon, A Adapa, E Urias, S Srinivasan, N Jairath, ...

CNS oncology 9 (2), CNS56.2020



Automated Intraoperative Frozen Diagnosis of Brain Tumors Using Machine Learning

SSS Khalsa, T Hollon, N Jairath, A Adapa, E Urias, K Eddy, J Szczepanski, ...

JOURNAL OF NEUROSURGERY 132 (4), 85-85.2020



Oncostreams: Self-organization and dynamics determine spatial heterogeneity and malignant behavior in gliomas

A Comba, S Motsch, PJ Dunn, TC Hollon, DB Zamler, AE Argento, ...

bioRxiv. 2020



Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

TC Hollon, B Pandian, AR Adapa, E Urias, AV Save, SSS Khalsa, ...

Nature medicine 26 (1), 52-58. 2020



Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

ML Schultz, MV Fawaz, RD Azaria, TC Hollon, EA Liu, TJ Kunkel, ...

BMC medicine 17 (1), 1-18. 2020



The feasibility of computer-assisted 3D navigation in multiple-level lateral lumbar interbody fusion in combination with posterior instrumentation for adult spinal deformity.

Strong MJ, Yee TJ, Khalsa SSS, Saadeh YS, Swong KN, Kashlan ON, Szerlip NJ, Park P, Oppenlander ME. Neurosurg Focus. 2020 Sep;49(3):E4.


2019



TMOD-14. RADIOGRAPHIC, STIMULATED RAMAN HISTOLOGIC, AND MULTIPLEXED RNA-SEQUENCING ANALYSIS OF POST-TREATMENT RECURRENT HIGH-GRADE GLIOMAS

A Save, T Hollon, Z Farooq, D Boyett, A Hawkins-Daarud, H Yoon, ...

Neuro-oncology 21 (Supplement_6), vi265-vi265. 2019



NIMG-69. RAPID INTRAOPERATIVE DIAGNOSIS OF GLIOMA RECURRENCE USING STIMULATED RAMAN HISTOLOGY AND DEEP NEURAL NETWORKS

T Hollon, E Urias, A Adapa, N Jairath, A Save, PD Canoll, H Lee, ...

Neuro-oncology 21 (Suppl 6), vi177. 2019



Near Real-Time Intraoperative Brain Tumor Diagnosis Using Stimulated Raman Histology and Deep Neural Networks

TC Hollon, B Pandian, SSS Khalsa, R D’Amico, MB Sisti, JN Bruce, ...

Neurosurgery 66 (Supplement_1), nyz310_634. 2019



Rapid Intraoperative Diagnosis of Sellar Region Tumors Using Stimulated Raman Histology

JR Linzey, TC Hollon, N Jairath, E Mckean, SE Sullivan, ...

Journal of Neurological Surgery Part B: Skull Base 80 (S 01), A140. 2019



Surgical adjuncts to increase the extent of resection: intraoperative MRI, fluorescence, and Raman histology

T Hollon, W Stummer, D Orringer, ES Molina

Neurosurgery Clinics 30 (1), 65-74. 2019



NIMG-33. MULTICENTER, PROSPECTIVE VALIDATION OF AUTOMATED INTRAOPERATIVE NEUROPATHOLOGY USING STIMULATED RAMAN HISTOLOGY AND CONVOLUTIONAL NEURAL NETWORKS

T Hollon, B Pandian, J Heth, O Sagher, C Maher, S Sullivan, H Garton, ...

Neuro-oncology 20 (suppl_6), vi183-vi183. 2019



Radiographic outcomes of endoscopic decompression for lumbar spinal stenosis.

Khalsa SS, Kim HS, Singh R, Kashlan ON.

Neurosurg Focus. 2019 May 1;46(5):E10.




2018


A machine learning approach to predict early outcomes after pituitary adenoma surgery

TC Hollon, A Parikh, B Pandian, J Tarpeh, DA Orringer, AL Barkan, ...

Neurosurgical focus 45 (5), E8. 2018



Raman Spectroscopy and Brain Tumors

TC Hollon, SN Kalkanis, DA Orringer

Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular …

2018


Clinical factors associated with ICU-specific care following supratentoral brain tumor resection and validation of a risk prediction score

LR Franko, T Hollon, J Linzey, C Roark, V Rajajee, K Sheehan, M Teig, ...

Critical care medicine 46 (8), 1302-1308. 2018



Ventriculoscopic Surgery for Cystic Retrochiasmatic Craniopharyngiomas: Indications, Surgical Technique, and Short-Term Patient Outcomes

TC Hollon, LE Savastano, D Altshuler, AL Barkan, SE Sullivan

Operative Neurosurgery 15 (2), 109-119.2018



Shedding light on IDH-1 mutation in gliomas

TC Hollon, DA Orringer

Clinical Cancer Research 24 (11), 2467-2469. 2018



Convolutional neural networks provide rapid intraoperative diagnosis of neurosurgical specimens imaged with Stimulated Raman histology

T Hollon, D Orringer

JOURNAL OF NEUROSURGERY 128 (4), 11-11. 2018


Microvascular brainstem ischemia after vestibular schwannoma surgery: a clinical and microanatomic study

TC Hollon, LE Savastano, DP Argersinger, DJ Quint, BG Thompson

World neurosurgery 112, e415-e424. 2018



Surgical treatment of olfactory neuroblastoma: major complication rates, progression free and overall survival

A Wertz, T Hollon, LJ Marentette, SE Sullivan, JB McHugh, EL McKean

Journal of neurological surgery. Part B, Skull base 79 (2), 151. 2018




Predicting Early Postoperative Outcomes after Pituitary Adenoma Surgery Using a Machine Learning Approach

TC Hollon, A Parikh, J Tarpeh, N Ibrahim, A Barkan, E Mckean, ...

Journal of Neurological Surgery Part B: Skull Base 79 (S 01), A158. 2018



Visual Acuity Outcome in Patients with Acute Pituitary Apoplexy after Hyperacute Transsphenoidal Surgery

N Ibrahim, T Hollon, J Trobe, A Barkan, SE Sullivan, EL McKean

Journal of Neurological Surgery Part B: Skull Base 79 (S 01), A137. 2018



Rapid intraoperative diagnosis of pediatric brain tumors using stimulated Raman histology

TC Hollon, S Lewis, B Pandian, YS Niknafs, MR Garrard, H Garton, ...

Cancer research 78 (1), 278-289. 2018



NIMG-22. RAPID ACCURATE INTRAOPERATIVE DIAGNOSIS OF PEDIATRIC BRAIN TUMORS USING STIMULATED RAMAN HISTOLOGY

TC Hollon, S Lewis, B Pandian, Y Niknafs, HJL Garton, CO Maher, ...



Morphometric and volumetric comparison of 102 children with symptomatic and asymptomatic Chiari malformation Type I.

Khalsa SSS, Geh N, Martin BA, Allen PA, Strahle J, Loth F, Habtzghi D, Urbizu Serrano A, McQuaide D, Garton HJL, Muraszko KM, Maher CO.

J Neurosurg Pediatr. 2018 Jan;21(1):65-71





2017


NIMG-35. DEEP CONVOLUTIONAL NEURAL NETWORKS PROVIDE RAPID DIAGNOSIS OF FRESH BRAIN TUMOR SPECIMENS IMAGED WITH STIMULATED RAMAN HISTOLOGY

TC Hollon, B Pandian, Y Niknafs, S Lewis, S Camelo-Piragua, ...

Neuro-oncology 19 (Suppl 6), vi149. 2017



Korsakoff syndrome from retrochiasmatic suprasellar lesions: rapid reversal after relief of cerebral compression in 4 cases

LE Savastano, TC Hollon, AL Barkan, SE Sullivan

Journal of neurosurgery 128 (6), 1731-1736. 2017



Stimulated Raman histology in brain tumors: A label free microscopic technique utilizing fresh unprocessed tissue

S Camelo-Piragua, S Camelo-Piragua, B Pandian, Y Niknafs, T Hollon, ...

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 76 (6), 525-525. 2017



TRTH-02. STIMULATED RAMAN SCATTERING MICROSCOPY PROVIDES RAPID, DIAGNOSTIC HISTOPATHOLOGIC IMAGES DURING PEDIATRIC BRAIN TUMOR SURGERY

T Hollon, M Garrard, J Tarpeh, B Pandian, Y Niknafs, H Garton, C Maher, ...

Neuro-Oncology. 2017



Virtual brain tumor histopathology and immunohistochemistry with stimulated raman scattering microscopy

SB Lewis, B Pandian, T Hollon, Y Niknafs, M Garrard, S Camelo-Piragua, ...

Journal of Clinical Oncology 35 (15_suppl), e13511-e13511. 2017



Spontaneous subarachnoid hemorrhage due to ruptured cavernous internal carotid artery aneurysm after medical prolactinoma treatment

SS Khalsa, TC Hollon, R Shastri, JD Trobe, JJ Gemmete, AS Pandey

Journal of neurointerventional surgery 9 (3), e9-e9. 2017



Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy

DA Orringer, B Pandian, YS Niknafs, TC Hollon, J Boyle, S Lewis, ...

Nature biomedical engineering 1 (2), 1-13. 2017



SURG-13. Stimulated Raman scattering microscopy provides diagnostic intraoperative histopathologic images in brain tumor patients

DA Orringer, B Pandian, TC Hollon, YS Niknafs, J Boyle, S Lewis, ...

Neuro-Oncology 18 (suppl_6), vi193-vi193. 2017



Fast and slide-free imaging.

Orringer, D.A., Camelo-Piragua, S.

Nat Biomed Eng 1, 926–928 (2017). https://doi.org/10.1038/s41551-017-0172-z



2016


Comparison of posterior fossa volumes and clinical outcomes after decompression of Chiari malformation Type I.

Khalsa SSS, Siu A, DeFreitas TA, Cappuzzo JM, Myseros JS, Magge SN, Oluigbo CO, Keating RF.

J Neurosurg Pediatr. 2017 May;19(5):511-517.



Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors

T Hollon, V Nguyen, BW Smith, S Lewis, L Junck, DA Orringer

Journal of neurosurgery 125 (2), 410-418. 2016



Surgical Management of Skull Base Rosai–Dorfman Disease

T Hollon, SI Camelo-Piragua, EL McKean, SE Sullivan, HJL Garton

World neurosurgery 87, 661. e5-661. e12. 2016



Improving the accuracy of brain tumor surgery via Raman-based technology

T Hollon, S Lewis, CW Freudiger, XS Xie, DA Orringer

Neurosurgical focus 40 (3), E9. 2016



Outcome of transsphenoidal surgery for Cushing disease: a single-center experience over 32 years

WF Chandler, AL Barkan, T Hollon, A Sakharova, J Sack, B Brahma, ...

Neurosurgery 78 (2), 216-223. 2016



Surgical Treatment of Esthesioneuroblastoma: Major Complication Rates, Progression-Free and Overall Survival

A Wertz, T Hollon, L Marentette, S Sullivan, E Mckean

Journal of Neurological Surgery Part B: Skull Base 77 (S 01), A003. 2016



Spontaneous subarachnoid hemorrhage due to ruptured cavernous internal carotid artery aneurysm after medical prolactinoma treatment

SS Khalsa, TC Hollon, R Shastri, JD Trobe, JJ Gemmete, AS Pandey

BMJ Case Reports 2016



Ruptured pediatric cerebellopontine angle epidermoid cyst: a case report detailing radiographic evolution and clinical course

Z Guan, T Hollon, JN Bentley, HJL Garton

Journal of Neurosurgery: Pediatrics 16 (5), 574-578. 2016



2015


Skull fracture mimicking eosinophilic granuloma

T Hollon, PE McKeever, HJL Garton, CO Maher

Child's Nervous System 31 (7), 1171-1174. 2015



Advances in the surgical management of low-grade glioma

T Hollon, SL Hervey-Jumper, O Sagher, DA Orringer

Seminars in radiation oncology 25 (3), 181-188. 2015



CYTOMEGALOVIRUS CONTRIBUTES TO GLIOBLASTOMA IN THE CONTEXT OF TUMOR SUPPRESSOR MUTATIONS

EA Chiocca, RL Price, T Hollon, C Alvarez-Breackenridge, S Fernandez, ...

Neuro-oncology 16 (Suppl 3), iii8. 2015


2014


Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus

TC Hollon, RL Price, CH Kwon, EA Chiocca

Oncoimmunology 2 (9), e25620. 2014


2013


Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations

RL Price, J Song, K Bingmer, TH Kim, JY Yi, MO Nowicki, X Mo, T Hollon, ...

Cancer research 73 (11), 3441-3450. 2013