Publications

2021


Abstract PR005: The dynamic tumor microenvironment: Oncostreams are self-organizing structures that modulate glioma progression and treatment

A Comba, S Motsch, P Dunn, T Hollon, D Zamler, A Argento, A Kahana, ...

Cancer Research 81 (5 Supplement), PR005-PR005. 2021

https://cancerres.aacrjournals.org/content/81/5_Supplement/PR005



SYSTEMS AND METHODS FOR ANALYSIS AND REMOTE INTERPRETATION OF OPTICAL HISTOLOGIC IMAGES

D Orringer, B Pandian, C Freudiger, T Hollon

US Patent App. 16/967,052.2021

https://patents.google.com/patent/US20210050094A1/en



Label-free brain tumor imaging using Raman-based methods

T Hollon, DA Orringer

Journal of neuro-oncology 151 (3), 393-402. 2021

https://pubmed.ncbi.nlm.nih.gov/33611706/



Rapid, label-free detection of diffuse glioma recurrence using intraoperative stimulated Raman histology and deep neural networks

TC Hollon, B Pandian, E Urias, AV Save, AR Adapa, S Srinivasan, ...

Neuro-oncology 23 (1), 144-155. 2021

https://pubmed.ncbi.nlm.nih.gov/32672793/



Normal cerebral ventricular volume growth in childhood

NS Cutler, S Srinivasan, BL Aaron, SK Anand, MS Kang, DB Altshuler, ...

Journal of Neurosurgery: Pediatrics 26 (5), 517-524. 2021

https://pubmed.ncbi.nlm.nih.gov/32823266/



Volumetric quantification of aneurysmal subarachnoid hemorrhage independently predicts hydrocephalus and seizures.

Daou BJ, Khalsa SSS, Anand SK, Williamson CA, Cutler NS, Aaron BL, Srinivasan S, Rajajee V, Sheehan K, Pandey AS.J Neurosurg. 2021 Feb 5:1-9.

https://pubmed.ncbi.nlm.nih.gov/33545677/



2020


An automated tissue-to-diagnosis pipeline using intraoperative stimulated Raman histology and deep learning

TC Hollon, DA Orringer

Molecular & cellular oncology 7 (3), 1736742.2020

https://pubmed.ncbi.nlm.nih.gov/32391430/



Automated histologic diagnosis of CNS tumors with machine learning

SSS Khalsa, TC Hollon, A Adapa, E Urias, S Srinivasan, N Jairath, ...

CNS oncology 9 (2), CNS56.2020

https://pubmed.ncbi.nlm.nih.gov/32602745/



Automated Intraoperative Frozen Diagnosis of Brain Tumors Using Machine Learning

SSS Khalsa, T Hollon, N Jairath, A Adapa, E Urias, K Eddy, J Szczepanski, ...

JOURNAL OF NEUROSURGERY 132 (4), 85-85.2020

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341168/



Oncostreams: Self-organization and dynamics determine spatial heterogeneity and malignant behavior in gliomas

A Comba, S Motsch, PJ Dunn, TC Hollon, DB Zamler, AE Argento, ...

bioRxiv. 2020

https://www.biorxiv.org/content/10.1101/2020.12.01.404970v1



Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

TC Hollon, B Pandian, AR Adapa, E Urias, AV Save, SSS Khalsa, ...

Nature medicine 26 (1), 52-58. 2020

https://pubmed.ncbi.nlm.nih.gov/31907460/



Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

ML Schultz, MV Fawaz, RD Azaria, TC Hollon, EA Liu, TJ Kunkel, ...

BMC medicine 17 (1), 1-18. 2020

https://pubmed.ncbi.nlm.nih.gov/31711490/



The feasibility of computer-assisted 3D navigation in multiple-level lateral lumbar interbody fusion in combination with posterior instrumentation for adult spinal deformity.

Strong MJ, Yee TJ, Khalsa SSS, Saadeh YS, Swong KN, Kashlan ON, Szerlip NJ, Park P, Oppenlander ME. Neurosurg Focus. 2020 Sep;49(3):E4.

https://pubmed.ncbi.nlm.nih.gov/32871568/


2019



TMOD-14. RADIOGRAPHIC, STIMULATED RAMAN HISTOLOGIC, AND MULTIPLEXED RNA-SEQUENCING ANALYSIS OF POST-TREATMENT RECURRENT HIGH-GRADE GLIOMAS

A Save, T Hollon, Z Farooq, D Boyett, A Hawkins-Daarud, H Yoon, ...

Neuro-oncology 21 (Supplement_6), vi265-vi265. 2019

https://academic.oup.com/neuro-oncology/article-abstract/21/Supplement_6/vi265/5620039?redirectedFrom=fulltext



NIMG-69. RAPID INTRAOPERATIVE DIAGNOSIS OF GLIOMA RECURRENCE USING STIMULATED RAMAN HISTOLOGY AND DEEP NEURAL NETWORKS

T Hollon, E Urias, A Adapa, N Jairath, A Save, PD Canoll, H Lee, ...

Neuro-oncology 21 (Suppl 6), vi177. 2019

https://academic.oup.com/neuro-oncology/article-abstract/21/Supplement_6/vi177/5620203?redirectedFrom=fulltext



Near Real-Time Intraoperative Brain Tumor Diagnosis Using Stimulated Raman Histology and Deep Neural Networks

TC Hollon, B Pandian, SSS Khalsa, R D’Amico, MB Sisti, JN Bruce, ...

Neurosurgery 66 (Supplement_1), nyz310_634. 2019

https://pubmed.ncbi.nlm.nih.gov/31907460/



Rapid Intraoperative Diagnosis of Sellar Region Tumors Using Stimulated Raman Histology

JR Linzey, TC Hollon, N Jairath, E Mckean, SE Sullivan, ...

Journal of Neurological Surgery Part B: Skull Base 80 (S 01), A140. 2019

https://pubmed.ncbi.nlm.nih.gov/29093006/



Surgical adjuncts to increase the extent of resection: intraoperative MRI, fluorescence, and Raman histology

T Hollon, W Stummer, D Orringer, ES Molina

Neurosurgery Clinics 30 (1), 65-74. 2019

https://pubmed.ncbi.nlm.nih.gov/30470406/



NIMG-33. MULTICENTER, PROSPECTIVE VALIDATION OF AUTOMATED INTRAOPERATIVE NEUROPATHOLOGY USING STIMULATED RAMAN HISTOLOGY AND CONVOLUTIONAL NEURAL NETWORKS

T Hollon, B Pandian, J Heth, O Sagher, C Maher, S Sullivan, H Garton, ...

Neuro-oncology 20 (suppl_6), vi183-vi183. 2019

https://academic.oup.com/neuro-oncology/article/20/suppl_6/vi183/5153448



Radiographic outcomes of endoscopic decompression for lumbar spinal stenosis.

Khalsa SS, Kim HS, Singh R, Kashlan ON.

Neurosurg Focus. 2019 May 1;46(5):E10.

https://pubmed.ncbi.nlm.nih.gov/31042651/



2018


A machine learning approach to predict early outcomes after pituitary adenoma surgery

TC Hollon, A Parikh, B Pandian, J Tarpeh, DA Orringer, AL Barkan, ...

Neurosurgical focus 45 (5), E8. 2018

https://pubmed.ncbi.nlm.nih.gov/30453460/



Raman Spectroscopy and Brain Tumors

TC Hollon, SN Kalkanis, DA Orringer

Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular …

2018


Clinical factors associated with ICU-specific care following supratentoral brain tumor resection and validation of a risk prediction score

LR Franko, T Hollon, J Linzey, C Roark, V Rajajee, K Sheehan, M Teig, ...

Critical care medicine 46 (8), 1302-1308. 2018

https://pubmed.ncbi.nlm.nih.gov/29742589/



Ventriculoscopic Surgery for Cystic Retrochiasmatic Craniopharyngiomas: Indications, Surgical Technique, and Short-Term Patient Outcomes

TC Hollon, LE Savastano, D Altshuler, AL Barkan, SE Sullivan

Operative Neurosurgery 15 (2), 109-119.2018

https://pubmed.ncbi.nlm.nih.gov/29048572/



Shedding light on IDH-1 mutation in gliomas

TC Hollon, DA Orringer

Clinical Cancer Research 24 (11), 2467-2469. 2018

https://pubmed.ncbi.nlm.nih.gov/29440182/



Convolutional neural networks provide rapid intraoperative diagnosis of neurosurgical specimens imaged with Stimulated Raman histology

T Hollon, D Orringer

JOURNAL OF NEUROSURGERY 128 (4), 11-11. 2018



Microvascular brainstem ischemia after vestibular schwannoma surgery: a clinical and microanatomic study

TC Hollon, LE Savastano, DP Argersinger, DJ Quint, BG Thompson

World neurosurgery 112, e415-e424. 2018

https://pubmed.ncbi.nlm.nih.gov/29355807/



Surgical treatment of olfactory neuroblastoma: major complication rates, progression free and overall survival

A Wertz, T Hollon, LJ Marentette, SE Sullivan, JB McHugh, EL McKean

Journal of neurological surgery. Part B, Skull base 79 (2), 151. 2018

https://pubmed.ncbi.nlm.nih.gov/29868319/



Predicting Early Postoperative Outcomes after Pituitary Adenoma Surgery Using a Machine Learning Approach

TC Hollon, A Parikh, J Tarpeh, N Ibrahim, A Barkan, E Mckean, ...

Journal of Neurological Surgery Part B: Skull Base 79 (S 01), A158. 2018



Visual Acuity Outcome in Patients with Acute Pituitary Apoplexy after Hyperacute Transsphenoidal Surgery

N Ibrahim, T Hollon, J Trobe, A Barkan, SE Sullivan, EL McKean

Journal of Neurological Surgery Part B: Skull Base 79 (S 01), A137. 2018



Rapid intraoperative diagnosis of pediatric brain tumors using stimulated Raman histology

TC Hollon, S Lewis, B Pandian, YS Niknafs, MR Garrard, H Garton, ...

Cancer research 78 (1), 278-289. 2018

https://pubmed.ncbi.nlm.nih.gov/29093006/



NIMG-22. RAPID ACCURATE INTRAOPERATIVE DIAGNOSIS OF PEDIATRIC BRAIN TUMORS USING STIMULATED RAMAN HISTOLOGY

TC Hollon, S Lewis, B Pandian, Y Niknafs, HJL Garton, CO Maher, ...

Neuro-oncology 19 (Suppl 6), vi146. 2018



Morphometric and volumetric comparison of 102 children with symptomatic and asymptomatic Chiari malformation Type I.

Khalsa SSS, Geh N, Martin BA, Allen PA, Strahle J, Loth F, Habtzghi D, Urbizu Serrano A, McQuaide D, Garton HJL, Muraszko KM, Maher CO.

J Neurosurg Pediatr. 2018 Jan;21(1):65-71

https://pubmed.ncbi.nlm.nih.gov/29125445/



2017


NIMG-35. DEEP CONVOLUTIONAL NEURAL NETWORKS PROVIDE RAPID DIAGNOSIS OF FRESH BRAIN TUMOR SPECIMENS IMAGED WITH STIMULATED RAMAN HISTOLOGY

TC Hollon, B Pandian, Y Niknafs, S Lewis, S Camelo-Piragua, ...

Neuro-oncology 19 (Suppl 6), vi149. 2017



Korsakoff syndrome from retrochiasmatic suprasellar lesions: rapid reversal after relief of cerebral compression in 4 cases

LE Savastano, TC Hollon, AL Barkan, SE Sullivan

Journal of neurosurgery 128 (6), 1731-1736. 2017

https://pubmed.ncbi.nlm.nih.gov/28574307/



Stimulated Raman histology in brain tumors: A label free microscopic technique utilizing fresh unprocessed tissue

S Camelo-Piragua, S Camelo-Piragua, B Pandian, Y Niknafs, T Hollon, ...

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 76 (6), 525-525. 2017



TRTH-02. STIMULATED RAMAN SCATTERING MICROSCOPY PROVIDES RAPID, DIAGNOSTIC HISTOPATHOLOGIC IMAGES DURING PEDIATRIC BRAIN TUMOR SURGERY

T Hollon, M Garrard, J Tarpeh, B Pandian, Y Niknafs, H Garton, C Maher, ...

Neuro-Oncology. 2017



Virtual brain tumor histopathology and immunohistochemistry with stimulated raman scattering microscopy

SB Lewis, B Pandian, T Hollon, Y Niknafs, M Garrard, S Camelo-Piragua, ...

Journal of Clinical Oncology 35 (15_suppl), e13511-e13511. 2017

https://ascopubs.org/doi/10.1200/JCO.2017.35.15_suppl.e13511



Spontaneous subarachnoid hemorrhage due to ruptured cavernous internal carotid artery aneurysm after medical prolactinoma treatment

SS Khalsa, TC Hollon, R Shastri, JD Trobe, JJ Gemmete, AS Pandey

Journal of neurointerventional surgery 9 (3), e9-e9. 2017



Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy

DA Orringer, B Pandian, YS Niknafs, TC Hollon, J Boyle, S Lewis, ...

Nature biomedical engineering 1 (2), 1-13. 2017

https://pubmed.ncbi.nlm.nih.gov/28955599/



SURG-13. Stimulated Raman scattering microscopy provides diagnostic intraoperative histopathologic images in brain tumor patients

DA Orringer, B Pandian, TC Hollon, YS Niknafs, J Boyle, S Lewis, ...

Neuro-Oncology 18 (suppl_6), vi193-vi193. 2017



Fast and slide-free imaging.

Orringer, D.A., Camelo-Piragua, S.

Nat Biomed Eng 1, 926–928 (2017). https://doi.org/10.1038/s41551-017-0172-z

https://pubmed.ncbi.nlm.nih.gov/31015705/



2016


Comparison of posterior fossa volumes and clinical outcomes after decompression of Chiari malformation Type I.

Khalsa SSS, Siu A, DeFreitas TA, Cappuzzo JM, Myseros JS, Magge SN, Oluigbo CO, Keating RF.

J Neurosurg Pediatr. 2017 May;19(5):511-517.

https://pubmed.ncbi.nlm.nih.gov/28291422/



Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors

T Hollon, V Nguyen, BW Smith, S Lewis, L Junck, DA Orringer

Journal of neurosurgery 125 (2), 410-418. 2016

https://pubmed.ncbi.nlm.nih.gov/26745489/



Surgical Management of Skull Base Rosai–Dorfman Disease

T Hollon, SI Camelo-Piragua, EL McKean, SE Sullivan, HJL Garton

World neurosurgery 87, 661. e5-661. e12. 2016

https://pubmed.ncbi.nlm.nih.gov/26316397/



Improving the accuracy of brain tumor surgery via Raman-based technology

T Hollon, S Lewis, CW Freudiger, XS Xie, DA Orringer

Neurosurgical focus 40 (3), E9. 2016

https://pubmed.ncbi.nlm.nih.gov/26926067/



Outcome of transsphenoidal surgery for Cushing disease: a single-center experience over 32 years

WF Chandler, AL Barkan, T Hollon, A Sakharova, J Sack, B Brahma, ...

Neurosurgery 78 (2), 216-223. 2016

https://pubmed.ncbi.nlm.nih.gov/26348007/



Surgical Treatment of Esthesioneuroblastoma: Major Complication Rates, Progression-Free and Overall Survival

A Wertz, T Hollon, L Marentette, S Sullivan, E Mckean

Journal of Neurological Surgery Part B: Skull Base 77 (S 01), A003. 2016



Spontaneous subarachnoid hemorrhage due to ruptured cavernous internal carotid artery aneurysm after medical prolactinoma treatment

SS Khalsa, TC Hollon, R Shastri, JD Trobe, JJ Gemmete, AS Pandey

BMJ Case Reports 2016

https://pubmed.ncbi.nlm.nih.gov/27305926/



Ruptured pediatric cerebellopontine angle epidermoid cyst: a case report detailing radiographic evolution and clinical course

Z Guan, T Hollon, JN Bentley, HJL Garton

Journal of Neurosurgery: Pediatrics 16 (5), 574-578. 2016

https://pubmed.ncbi.nlm.nih.gov/26295366/



2015


Skull fracture mimicking eosinophilic granuloma

T Hollon, PE McKeever, HJL Garton, CO Maher

Child's Nervous System 31 (7), 1171-1174. 2015

https://pubmed.ncbi.nlm.nih.gov/25758644/



Advances in the surgical management of low-grade glioma

T Hollon, SL Hervey-Jumper, O Sagher, DA Orringer

Seminars in radiation oncology 25 (3), 181-188. 2015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460567/



CYTOMEGALOVIRUS CONTRIBUTES TO GLIOBLASTOMA IN THE CONTEXT OF TUMOR SUPPRESSOR MUTATIONS

EA Chiocca, RL Price, T Hollon, C Alvarez-Breackenridge, S Fernandez, ...

Neuro-oncology 16 (Suppl 3), iii8. 2015

https://pubmed.ncbi.nlm.nih.gov/23729642/


2014


Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus

TC Hollon, RL Price, CH Kwon, EA Chiocca

Oncoimmunology 2 (9), e25620. 2014

https://pubmed.ncbi.nlm.nih.gov/24319635/


2013


Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations

RL Price, J Song, K Bingmer, TH Kim, JY Yi, MO Nowicki, X Mo, T Hollon, ...

Cancer research 73 (11), 3441-3450. 2013

https://pubmed.ncbi.nlm.nih.gov/23729642/